The standard typing profile of our in-house developed high-throughput typing software neXtype included so far HLA genes A, B, C, E, DRB1, DQB1, DPB1, MICA, and MICB as well as genes for ABO, RhD, CCR5, and KIR. Given recent indicationsa that the class II genes DRB3/4/5, DQA1, and DPA1 could also play an important role in the outcome of unrelated hematopoeitic stem cell transplantation, we extended in October 2019 our typing profile accordingly. While for DQA1 and DPA1 the standard algorithm is used (as for the already established HLA loci), for DRB3/4/5 an adjustment was needed. Since the copy number (CN) for DRB3/4/5 is not fixed to two the previously established linkage disequilibrium (LD) with DRB1b,c is used in order to determine the actual CN for those loci.